Ocimum tenuiflorum ocimum sanctum belongs to the family of lamiaceae and is commonly known as thulasitulsi in india. Page 1 queen of herbs tulsi ocimum sanctum removes impurities from water and plays disinfectant role babita labh kayastha 1 1. Evaluating medicinal plants for anticancer activity. Anxiety and depression are the major psychological disorder found in people all over the globe. A potential source of anticancer agent and its role in restoration of maspin via snail and hdacs in breast cancer thesis submitted to. Antimicrobial activity of ocimum sanctum extract was carried out using well diffusion method by comparing the clear inhibition zone of standard antibiotic and. Antioxidant potential of the os extract was evaluated in vitro by dpph 1, 1diphenyl2picrylhydrazyl and no nitric oxide scavenging assay and reducing power assay method. Compounds 6, 7, 9, 11, 12, and, along with the methanol. Experimental studies identify it to be a highly promising immunomodulator, cytoprotective and anticancer agent. Ocimum sanctum tulsi is an indian medicinal plant known to possess hypoglycemic, hypolipidemic, immunomodulatory, adaptogenic, hepatoprotective, and cardioprotective activities. Different parts of ocimum sanctum like roots, stem, leaves, flowers and seeds possess medicinal properties and are used for treatment for many pathologic conditions as analgesic, antipyretic, anticancer, expectorant. The anticancer activity of os has been proved and cited by several investigators8 11.
A plant from genus ocimum among the plants known for medicinal value, the plants of genus ocimum belonging to family labiatae are very important for their therapeutic potentials. Because of high death rate associated with cancer and because of serious side effects of chemotherapy and radiation therapy, many cancer patients seek alternative complementary methods of treatment. Evaluation of some chemical composition, minerals fatty. Eugenol 1hydroxy2methoxy4allylbenzene is the active constituents present in ocimum sanctum linn. Ayurvedic system of medicine of ocimum sanctum for various aliment and has been show to significant antistress property. Ocimum contains fixed oil which is confirmed by chemical tests for glycerine. Circineol, gallic acid, vitamin a, vitamin c, phosphrous and iron. International journal of basic and applied research phytochemical screening, antimicrobial, antioxidant and anticancer activity of ocimum sanctum plant extract article aug 2018. Ocimum sanctum or holy basil is an ancient herb popular for its curative properties to treat number of health disorders. Antioxidant, anticancer and molecular docking activity of. Antiinflammatory activity of extracted eugenol from. Leaf extract of medicinally important plant ocimum sanctum o. In the steps, the four dried fractions were extracted and used for biogenic synthesis of gold nanoparticles. Therapeutic potential and phytopharmacology of tulsi.
Scientific studies have shown it to possess antiinflammatory, analgesic, antipyretic, antidiabetic, hepatoprotective, hypolipidemic. Promotes healthy heart holy basil contains vitamin c and antioxidants such as eugenol, which protects the heart from the harmful effects of free radicals. It is particularly good for reducing depression, stress and anxiety. Potentiating effect of betacaryophyllene on anticancer activity of alphahumulene, isocaryophyllene and paclitaxel. Different parts of the plant to be effectively in a number of diseases 16. Its leaves are helpful in sharpening memory and in curing fever and common cold. Qu has been conjugated with nigs for enhanced anticancer effect on human breast cancer mcf7 cells.
Evaluation of antidiabetic and antihyperlipidemic effects of hydroalcoholic extract of leaves of ocimum tenuiflorum lamiaceae and prediction of biological activity of its. Therapeutic activities of ocimum tenuiflorum accounted in. Ocimum sanctum has excellent antimalarial properties, eugenol the main constituent of this plant is responsible for its repellant property singh et al. The medicinal value of this herb is recognised by ayurveda. In vitro tests on oral pathogenic bacteria shows that ocimum sanctum l extract in the form of toothpastes, mouthwash, and gels have antibacterial activity against streptococcus mutans and.
Review article pharmacological activities of ocimum. Treatment with an ethanolic extract of ocimum sanctum induced cytotoxicity at 50 gml and above. Tulsi in hindi is an important medicinal plant, traditionally used in india. Phytochemical analysis, antibacterial and antioxidant. Formulation, evaluation and antibacterial efficiency of. Ocimum tenuiflorum an overview sciencedirect topics. These observations clearly indicate ocimum sanctum extracts possess anticancer activity. Pdf study of invitro antioxidant and antibacterial.
Not enough is known about the use of holy basil during pregnancy and breastfeeding. Holy basil is possibly safe when used by mouth for short periods of time, up to six weeks. Synergistic anticancer effect of green synthesized nickel. Evaluation of cardioprotective activity of ginkgo biloba. Phytochemical analysis for the important chemical constituents from ethanolic extract was carried out.
Ocimum sanctum contain several bioactive compounds may contribute to the health effects and are easily available for consumption to increase the nutritional status as well as act as safe guarding against possible deficiencies. Pdf the anticancer effect of ocimum tenuiflorum leaves. Evaluation of antidiabetic and antihyperlipidemic effects. Whole plant extracts ethanol extracted were prepared, coded as plant extract numbers 117, and tested for their potential as anticancer agents. The plant increased the physical endurance and prevented stressinduced ulcers. Tulsi named as queen of herbs of india and one of the holiest and. Ocimum sanctum linn is preeminent, and scientific research is now confirming its beneficial effects. Keywords ocimum sanctum, expectorant, stimulant, anthelmentic. Pdf in vitro and in vivo methods for anticancer activity. The phytochemical study of the nonpolar dichloromethane 100% and polar methanol.
Ocimum sanctums methanolic extract 500mg proved the inflammatory activity in rats. An overview article pdf available july 20 with 5,622 reads. Biosynthesis of gold nanoparticles using ocimum sanctum. Antimicrobial activity of tulsi ocimum tenuiflorum. Ocimum sanctum linn tulsi is a wellknown plant used in the indian system of medicine. This result has also been demonstrated by anticancer activity of ocimum sanctum in lewis lung carcinoma animal model.
Screening of siddha medicinal plants for anti cancer. Different parts of plant ocimum sanctum possess anticancer, antifertility, antidiabetic, antifungal, hepatoprotective, cardioprotective and analgesic properties. Os, tulsi, a medicinal herb used in the indigenous system of medicine. The antifungal activity of the essential oil of ocimum. In vitro and in vivo methods for anticancer activity evaluation and some indian medicinal plants possessing anticancer properties. The genus ocimum has a number of species that are used to treat different types of disorders and diseases from ancient times. The best known species are the strongly aromatic herb ocimum basilicum thai basil and ocimum gratissimum african basil as well as the medicinal herb ocimum tenuiflorum, also known as ocimum sanctum holy basil or tulsi in hindi. Medicinal properties, ocimum sanctum os, tulsi, pharmacological activities. Ocimum sanctum is an aromatic plant in the family lamiaceae which is native to the indian subcontinent.
The present study was designed to investigate the antioxidant and anti neoplastic activities of ocimum sanctum linn. Studies of antimicrobial properties of different leaf. Phytochemical screening and antioxidant activity of. Study on anticancer effects of ocimum sanctum and withania somnifera on experimentally induced cancer in mice. Ocimum sanctum plant leaves were subject to sequential solvent fractionation with different polarity hexane, chloroform, nbutanol and water. Labiatae, a plant with various medicinal properties, has been investigated against human fibrosarcoma cells hfs cells in culture. Fixed oil and linolenic acid present in tulsi have the ability to. Os extract showed prominent scavenging activity in all the methods with. Administration of aqueous and ethanolic extracts of ocimum sanctum to mice bearing sarcoma180 solid tumors mediated a significant reduction in tumor volume and an increase in lifespan. In vitro antioxidant and antineoplastic activities of. Tulsi the wonder herb pharmacological activities of.
Evaluation of some chemical composition, minerals fatty acid profiles, antioxidant and antimicrobial activities of tulsi ocimum sanctum from india. Pharmacological activity anticancer activity in ayurveda, various plants are used as a potential source of anticancer and antitumor properties. Pdf abstract breast cancer is the leading cause of cancer deaths among females in malaysia. Study of invitro antioxidant and antibacterial activity of leaf extract of azadirachta indica and ocimum sanctum in different organic solvents and cow urine. Medicines free fulltext antiproliferative activity of.
Phytochemical analysis of medicinal herb ocimum sanctum. In conclusion this article provides the knowledge about anticancer. Antibacterial, antifungal, antioxidant, anticancer, antiulcer pharmacological properties of ocimum species viz. Ocimum sanctum has been shown to possess multifarious medicinal properties such analgesic activity, antiulcer activity, antiarthritic activity, immunomodulatory activity, antiasthmatic activity, antifertility activity, anticancer activity, anticonvulsant activity. These observations conclude ocimum sanctum extracts possess anticancer activity22. Cancer is the abnormal growth of cells in our bodies that can lead to death. It is universally cultivated as herbaceous, perennial plant but originated from asian continent. The results of antioxidant activity of tulsi leaves extract showed that tulsi leaves has good free radical scavenging ability and ic50 value was found to be 54. Ocimum sanctum is an annual herb belonging to the mint family with 150 varieties worldwide. P, india abstract ocimum sanctum is an annual herb belonging to the mint family with 150 varieties worldwide. Constituents of the essential oil from the holy basil or tulsi plant, ocimum sanctum.
Anticancer property of ocimum sanctum the experimental studies carried out on biological models using os extract on fibrosarcoma cells in culture have demonstrated that ocimum sanctum exhibits anticancer activity. Diversified potentials of ocimum sanctum linn tulsi. An investigation was carried out to study the antioxidant, anticancer and docking activities of medicinal plant, tulsi ocimum sanctum. They observed that, the ocimum sanctum linn has also been suggested to possess, anticancer, antidiabetic, antifertility, antifungal, antimicrobial, cardio protective, analgesic, antispasmodic and adaptogenic actions. Therapeutic potential of ocimum sanctum in prevention and.
P sims college of pharmacy, mangaldas nagar, guntur, a. Review article chemical constituents and pharmacological. It is believed to purify expectorants, and called the wonder herb. It has been found that ethanolic extract of ocimum sanctum mediated a significant reduction in tumor cell size and an increase in lifespan of mice having sarcoma180 solid tumors 10. Herbs have been provided therapeutic potential to the health of individual. Basil is the main ingredient of pesto sauce but is also used to flavor other sauces and soups. Tulsi the wonder herb pharmacological activities of ocimum sanctum sai krishna. Ocimum sanctum is held sacred by hindus and is used as medicinal plants in day to day practice in indian homes for various ailments. Introduction tulsi is an important symbol of the hindu religious. Labiateae or lamiaceae comprises 30 species which are found in tropical and subtropical regions. Leaves and flowering tops are used for extracting essential oil.
1095 161 5 725 931 847 1115 1436 893 1091 781 97 651 1383 1251 864 1102 445 858 1141 1388 545 606 716 18 503 851 123